diff --git a/packages/vite/package.json b/packages/vite/package.json
index e619c78c28..ccd4b2c33c 100644
--- a/packages/vite/package.json
+++ b/packages/vite/package.json
@@ -49,7 +49,7 @@
     "ufo": "^0.8.5",
     "unplugin": "^0.9.2",
     "vite": "~3.0.8",
-    "vite-node": "^0.22.0",
+    "vite-node": "^0.22.1",
     "vite-plugin-checker": "^0.4.9",
     "vue-bundle-renderer": "^0.4.2"
   },
diff --git a/packages/vite/src/runtime/vite-node.mjs b/packages/vite/src/runtime/vite-node.mjs
index a4c5d93350..3a12d90edc 100644
--- a/packages/vite/src/runtime/vite-node.mjs
+++ b/packages/vite/src/runtime/vite-node.mjs
@@ -27,12 +27,7 @@ export default async (ssrContext) => {
   const invalidates = await $fetch('/invalidates', {
     baseURL: viteNodeOptions.baseURL
   })
-  const updates = new Set()
-  for (const key of invalidates) {
-    if (runner.moduleCache.delete(key)) {
-      updates.add(key)
-    }
-  }
+  const updates = runner.moduleCache.invalidateDepTree(invalidates)
 
   // Execute SSR bundle on demand
   const start = performance.now()
diff --git a/packages/vite/src/vite-node.ts b/packages/vite/src/vite-node.ts
index 55bfd7c2af..743b3a674e 100644
--- a/packages/vite/src/vite-node.ts
+++ b/packages/vite/src/vite-node.ts
@@ -78,14 +78,6 @@ function createViteNodeMiddleware (ctx: ViteBuildContext, invalidates: Set<strin
   }))
 
   app.use('/invalidates', defineEventHandler(() => {
-    // When a file has been invalidated, we also invalidate the entry module
-    if (invalidates.size) {
-      for (const key of ctx.ssrServer!.moduleGraph.fileToModulesMap.keys()) {
-        if (key.startsWith(ctx.nuxt.options.appDir + '/entry')) {
-          invalidates.add(key)
-        }
-      }
-    }
     const ids = Array.from(invalidates)
     invalidates.clear()
     return ids
diff --git a/yarn.lock b/yarn.lock
index 46540bf9d5..f3861b6c37 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -1815,7 +1815,7 @@ __metadata:
     unbuild: latest
     unplugin: ^0.9.2
     vite: ~3.0.8
-    vite-node: ^0.22.0
+    vite-node: ^0.22.1
     vite-plugin-checker: ^0.4.9
     vue: 3.2.37
     vue-bundle-renderer: ^0.4.2
@@ -13488,9 +13488,9 @@ __metadata:
   languageName: node
   linkType: hard
 
-"vite-node@npm:^0.22.0":
-  version: 0.22.0
-  resolution: "vite-node@npm:0.22.0"
+"vite-node@npm:^0.22.1":
+  version: 0.22.1
+  resolution: "vite-node@npm:0.22.1"
   dependencies:
     debug: ^4.3.4
     mlly: ^0.5.12
@@ -13498,7 +13498,7 @@ __metadata:
     vite: ^2.9.12 || ^3.0.0-0
   bin:
     vite-node: vite-node.mjs
-  checksum: 2b5552b2ae1e20bf139e6b88e2b59910f4cedd01a9355b6bfbf3d10d36cb5979660a83e47e9db4c1523b874441c7a1498074bef6dc47c14cc3ace857eceaec13
+  checksum: 29a4edb4e3f1344a4334dd46ce8e023862831c74a8aca0266c625fbfbdc5a31e83bb64992b08a82249c8a298d5bbbf84bc27ff6af5fe60514e307008443a2d2a
   languageName: node
   linkType: hard