diff --git a/packages/nuxt/src/core/nitro.ts b/packages/nuxt/src/core/nitro.ts
index 57d5394cdf..7273aadacd 100644
--- a/packages/nuxt/src/core/nitro.ts
+++ b/packages/nuxt/src/core/nitro.ts
@@ -227,3 +227,9 @@ async function resolveHandlers (nuxt: Nuxt) {
     devHandlers
   }
 }
+
+declare module 'nitropack' {
+  interface NitroRouteOption {
+    ssr?: boolean
+  }
+}
diff --git a/packages/nuxt/src/core/runtime/nitro/renderer.ts b/packages/nuxt/src/core/runtime/nitro/renderer.ts
index 828aec1a84..8567b162f4 100644
--- a/packages/nuxt/src/core/runtime/nitro/renderer.ts
+++ b/packages/nuxt/src/core/runtime/nitro/renderer.ts
@@ -3,6 +3,7 @@ import type { RenderResponse } from 'nitropack'
 import type { Manifest } from 'vite'
 import { appendHeader, getQuery } from 'h3'
 import devalue from '@nuxt/devalue'
+import { createRouter as createMatcher } from 'radix3'
 import { joinURL } from 'ufo'
 import { renderToString as _renderToString } from 'vue/server-renderer'
 import { useRuntimeConfig, useNitroApp, defineRenderHandler } from '#internal/nitro'
@@ -106,6 +107,9 @@ const getSPARenderer = lazyCachedFunction(async () => {
   }
 })
 
+// Set up route rule matcher
+const routerOptions = createMatcher({ routes: useRuntimeConfig().nitro.routes })
+
 const PAYLOAD_CACHE = (process.env.NUXT_PAYLOAD_EXTRACTION && process.env.prerender) ? new Map() : null // TODO: Use LRU cache
 const PAYLOAD_URL_RE = /\/_payload(\.[a-zA-Z0-9]+)?.js(\?.*)?$/
 
@@ -128,6 +132,9 @@ export default defineRenderHandler(async (event) => {
     }
   }
 
+  // TODO: share across endpoints on event context
+  const routeOptions = event.context.routeOptions || routerOptions.lookup(url) || {}
+
   // Initialize ssr context
   const ssrContext: NuxtSSRContext = {
     url,
@@ -138,6 +145,7 @@ export default defineRenderHandler(async (event) => {
     noSSR:
       !!(process.env.NUXT_NO_SSR) ||
       !!(event.req.headers['x-nuxt-no-ssr']) ||
+      routeOptions.ssr === false ||
       (process.env.prerender ? PRERENDER_NO_SSR_ROUTES.has(url) : false),
     error: !!ssrError,
     nuxt: undefined!, /* NuxtApp */
diff --git a/test/basic.test.ts b/test/basic.test.ts
index cc964d76fc..65acabfea1 100644
--- a/test/basic.test.ts
+++ b/test/basic.test.ts
@@ -29,6 +29,12 @@ describe('server api', () => {
   })
 })
 
+describe('route rules', () => {
+  it('should enable spa mode', async () => {
+    expect(await $fetch('/route-rules/spa')).toContain('serverRendered:false')
+  })
+})
+
 describe('pages', () => {
   it('render index', async () => {
     const html = await $fetch('/')
diff --git a/test/fixtures/basic/nuxt.config.ts b/test/fixtures/basic/nuxt.config.ts
index 2412474c4c..01c53364ea 100644
--- a/test/fixtures/basic/nuxt.config.ts
+++ b/test/fixtures/basic/nuxt.config.ts
@@ -19,6 +19,9 @@ export default defineNuxtConfig({
     './extends/node_modules/foo'
   ],
   nitro: {
+    routes: {
+      '/route-rules/spa': { ssr: false }
+    },
     output: { dir: process.env.NITRO_OUTPUT_DIR },
     prerender: {
       routes: [
diff --git a/test/fixtures/basic/pages/route-rules/spa.vue b/test/fixtures/basic/pages/route-rules/spa.vue
new file mode 100644
index 0000000000..6777da5c53
--- /dev/null
+++ b/test/fixtures/basic/pages/route-rules/spa.vue
@@ -0,0 +1,5 @@
+<template>
+  <div>
+    should not be rendered on ssr
+  </div>
+</template>