diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 4ce9cff57..133eb6df4 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -30,6 +30,11 @@ repos:
   - id: fix-encoding-pragma
     exclude: ^noxfile.py$
 
+- repo: https://github.com/asottile/pyupgrade
+  rev: v2.21.0
+  hooks:
+  - id: pyupgrade
+
 # Black, the code formatter, natively supports pre-commit
 - repo: https://github.com/psf/black
   rev: 21.6b0
diff --git a/tests/extra_python_package/test_files.py b/tests/extra_python_package/test_files.py
index c1d12ed76..43e93c263 100644
--- a/tests/extra_python_package/test_files.py
+++ b/tests/extra_python_package/test_files.py
@@ -126,7 +126,7 @@ def test_build_sdist(monkeypatch, tmpdir):
     with tarfile.open(str(sdist)) as tar:
         start = tar.getnames()[0] + "/"
         version = start[9:-1]
-        simpler = set(n.split("/", 1)[-1] for n in tar.getnames()[1:])
+        simpler = {n.split("/", 1)[-1] for n in tar.getnames()[1:]}
 
         with contextlib.closing(
             tar.extractfile(tar.getmember(start + "setup.py"))
@@ -138,9 +138,9 @@ def test_build_sdist(monkeypatch, tmpdir):
         ) as f:
             pyproject_toml = f.read()
 
-    files = set("pybind11/{}".format(n) for n in all_files)
+    files = {"pybind11/{}".format(n) for n in all_files}
     files |= sdist_files
-    files |= set("pybind11{}".format(n) for n in local_sdist_files)
+    files |= {"pybind11{}".format(n) for n in local_sdist_files}
     files.add("pybind11.egg-info/entry_points.txt")
     files.add("pybind11.egg-info/requires.txt")
     assert simpler == files
@@ -181,7 +181,7 @@ def test_build_global_dist(monkeypatch, tmpdir):
     with tarfile.open(str(sdist)) as tar:
         start = tar.getnames()[0] + "/"
         version = start[16:-1]
-        simpler = set(n.split("/", 1)[-1] for n in tar.getnames()[1:])
+        simpler = {n.split("/", 1)[-1] for n in tar.getnames()[1:]}
 
         with contextlib.closing(
             tar.extractfile(tar.getmember(start + "setup.py"))
@@ -193,9 +193,9 @@ def test_build_global_dist(monkeypatch, tmpdir):
         ) as f:
             pyproject_toml = f.read()
 
-    files = set("pybind11/{}".format(n) for n in all_files)
+    files = {"pybind11/{}".format(n) for n in all_files}
     files |= sdist_files
-    files |= set("pybind11_global{}".format(n) for n in local_sdist_files)
+    files |= {"pybind11_global{}".format(n) for n in local_sdist_files}
     assert simpler == files
 
     with open(os.path.join(MAIN_DIR, "tools", "setup_global.py.in"), "rb") as f:
@@ -220,7 +220,7 @@ def tests_build_wheel(monkeypatch, tmpdir):
 
     (wheel,) = tmpdir.visit("*.whl")
 
-    files = set("pybind11/{}".format(n) for n in all_files)
+    files = {"pybind11/{}".format(n) for n in all_files}
     files |= {
         "dist-info/LICENSE",
         "dist-info/METADATA",
@@ -233,10 +233,10 @@ def tests_build_wheel(monkeypatch, tmpdir):
     with zipfile.ZipFile(str(wheel)) as z:
         names = z.namelist()
 
-    trimmed = set(n for n in names if "dist-info" not in n)
-    trimmed |= set(
+    trimmed = {n for n in names if "dist-info" not in n}
+    trimmed |= {
         "dist-info/{}".format(n.split("/", 1)[-1]) for n in names if "dist-info" in n
-    )
+    }
     assert files == trimmed
 
 
@@ -250,8 +250,8 @@ def tests_build_global_wheel(monkeypatch, tmpdir):
 
     (wheel,) = tmpdir.visit("*.whl")
 
-    files = set("data/data/{}".format(n) for n in src_files)
-    files |= set("data/headers/{}".format(n[8:]) for n in headers)
+    files = {"data/data/{}".format(n) for n in src_files}
+    files |= {"data/headers/{}".format(n[8:]) for n in headers}
     files |= {
         "dist-info/LICENSE",
         "dist-info/METADATA",
@@ -264,6 +264,6 @@ def tests_build_global_wheel(monkeypatch, tmpdir):
         names = z.namelist()
 
     beginning = names[0].split("/", 1)[0].rsplit(".", 1)[0]
-    trimmed = set(n[len(beginning) + 1 :] for n in names)
+    trimmed = {n[len(beginning) + 1 :] for n in names}
 
     assert files == trimmed
diff --git a/tests/test_builtin_casters.py b/tests/test_builtin_casters.py
index 99c400c30..1b9dbb2b4 100644
--- a/tests/test_builtin_casters.py
+++ b/tests/test_builtin_casters.py
@@ -50,7 +50,7 @@ def test_single_char_arguments():
     """Tests failures for passing invalid inputs to char-accepting functions"""
 
     def toobig_message(r):
-        return "Character code point not in range({0:#x})".format(r)
+        return "Character code point not in range({:#x})".format(r)
 
     toolong_message = "Expected a character, but multi-character string found"
 
diff --git a/tests/test_callbacks.py b/tests/test_callbacks.py
index 352661430..397bf63d2 100644
--- a/tests/test_callbacks.py
+++ b/tests/test_callbacks.py
@@ -144,7 +144,7 @@ def test_async_callbacks():
     from time import sleep
 
     sleep(0.5)
-    assert sum(res) == sum([x + 3 for x in work])
+    assert sum(res) == sum(x + 3 for x in work)
 
 
 def test_async_async_callbacks():
diff --git a/tests/test_pytypes.py b/tests/test_pytypes.py
index f234c7731..25e9f6dff 100644
--- a/tests/test_pytypes.py
+++ b/tests/test_pytypes.py
@@ -65,7 +65,7 @@ def test_set(capture, doc):
     """
     )
 
-    assert not m.set_contains(set([]), 42)
+    assert not m.set_contains(set(), 42)
     assert m.set_contains({42}, 42)
     assert m.set_contains({"foo"}, "foo")
 
@@ -448,7 +448,7 @@ def test_memoryview(method, args, fmt, expected_view):
         view_as_list = list(view)
     else:
         # Using max to pick non-zero byte (big-endian vs little-endian).
-        view_as_list = [max([ord(c) for c in s]) for s in view]
+        view_as_list = [max(ord(c) for c in s) for s in view]
     assert view_as_list == list(expected_view)