diff --git a/include/pybind11/detail/exception_translation.h b/include/pybind11/detail/exception_translation.h
index 2764180bb..22ae8a1c9 100644
--- a/include/pybind11/detail/exception_translation.h
+++ b/include/pybind11/detail/exception_translation.h
@@ -50,17 +50,17 @@ inline void try_translate_exceptions() {
         - delegate translation to the next translator by throwing a new type of exception.
         */
 
-    bool handled = with_internals([&](internals &internals) {
-        auto &local_exception_translators = get_local_internals().registered_exception_translators;
-        if (detail::apply_exception_translators(local_exception_translators)) {
-            return true;
-        }
-        auto &exception_translators = internals.registered_exception_translators;
-        if (detail::apply_exception_translators(exception_translators)) {
-            return true;
-        }
-        return false;
-    });
+    bool handled = with_exception_translators(
+        [&](std::forward_list<ExceptionTranslator> &exception_translators,
+            std::forward_list<ExceptionTranslator> &local_exception_translators) {
+            if (detail::apply_exception_translators(local_exception_translators)) {
+                return true;
+            }
+            if (detail::apply_exception_translators(exception_translators)) {
+                return true;
+            }
+            return false;
+        });
 
     if (!handled) {
         set_error(PyExc_SystemError, "Exception escaped from default exception translator!");
diff --git a/include/pybind11/detail/internals.h b/include/pybind11/detail/internals.h
index 7cc6f53ad..fa224e032 100644
--- a/include/pybind11/detail/internals.h
+++ b/include/pybind11/detail/internals.h
@@ -39,7 +39,11 @@
 #    if PY_VERSION_HEX >= 0x030C0000 || defined(_MSC_VER)
 // Version bump for Python 3.12+, before first 3.12 beta release.
 // Version bump for MSVC piggy-backed on PR #4779. See comments there.
-#        define PYBIND11_INTERNALS_VERSION 5
+#        ifdef Py_GIL_DISABLED
+#            define PYBIND11_INTERNALS_VERSION 6
+#        else
+#            define PYBIND11_INTERNALS_VERSION 5
+#        endif
 #    else
 #        define PYBIND11_INTERNALS_VERSION 4
 #    endif
@@ -177,6 +181,7 @@ static_assert(sizeof(instance_map_shard) % 64 == 0,
 struct internals {
 #ifdef Py_GIL_DISABLED
     pymutex mutex;
+    pymutex exception_translator_mutex;
 #endif
     // std::type_index -> pybind11's type information
     type_map<type_info *> registered_types_cpp;
@@ -643,6 +648,19 @@ inline auto with_internals(const F &cb) -> decltype(cb(get_internals())) {
     return cb(internals);
 }
 
+template <typename F>
+inline auto with_exception_translators(const F &cb)
+    -> decltype(cb(get_internals().registered_exception_translators,
+                   get_local_internals().registered_exception_translators)) {
+    auto &internals = get_internals();
+#ifdef Py_GIL_DISABLED
+    std::unique_lock<pymutex> lock((internals).exception_translator_mutex);
+#endif
+    auto &local_internals = get_local_internals();
+    return cb(internals.registered_exception_translators,
+              local_internals.registered_exception_translators);
+}
+
 inline std::uint64_t mix64(std::uint64_t z) {
     // David Stafford's variant 13 of the MurmurHash3 finalizer popularized
     // by the SplitMix PRNG.
diff --git a/include/pybind11/pybind11.h b/include/pybind11/pybind11.h
index c52df969e..bcdf641f4 100644
--- a/include/pybind11/pybind11.h
+++ b/include/pybind11/pybind11.h
@@ -2586,10 +2586,12 @@ void implicitly_convertible() {
 }
 
 inline void register_exception_translator(ExceptionTranslator &&translator) {
-    detail::with_internals([&](detail::internals &internals) {
-        internals.registered_exception_translators.push_front(
-            std::forward<ExceptionTranslator>(translator));
-    });
+    detail::with_exception_translators(
+        [&](std::forward_list<ExceptionTranslator> &exception_translators,
+            std::forward_list<ExceptionTranslator> &local_exception_translators) {
+            (void) local_exception_translators;
+            exception_translators.push_front(std::forward<ExceptionTranslator>(translator));
+        });
 }
 
 /**
@@ -2599,11 +2601,12 @@ inline void register_exception_translator(ExceptionTranslator &&translator) {
  * the exception.
  */
 inline void register_local_exception_translator(ExceptionTranslator &&translator) {
-    detail::with_internals([&](detail::internals &internals) {
-        (void) internals;
-        detail::get_local_internals().registered_exception_translators.push_front(
-            std::forward<ExceptionTranslator>(translator));
-    });
+    detail::with_exception_translators(
+        [&](std::forward_list<ExceptionTranslator> &exception_translators,
+            std::forward_list<ExceptionTranslator> &local_exception_translators) {
+            (void) exception_translators;
+            local_exception_translators.push_front(std::forward<ExceptionTranslator>(translator));
+        });
 }
 
 /**
diff --git a/tests/custom_exceptions.py b/tests/custom_exceptions.py
new file mode 100644
index 000000000..b1a092d76
--- /dev/null
+++ b/tests/custom_exceptions.py
@@ -0,0 +1,10 @@
+from __future__ import annotations
+
+
+class PythonMyException7(Exception):
+    def __init__(self, message):
+        self.message = message
+        super().__init__(message)
+
+    def __str__(self):
+        return "[PythonMyException7]: " + self.message.a
diff --git a/tests/test_exceptions.cpp b/tests/test_exceptions.cpp
index c1d05bb24..0a970065b 100644
--- a/tests/test_exceptions.cpp
+++ b/tests/test_exceptions.cpp
@@ -111,6 +111,16 @@ struct PythonAlreadySetInDestructor {
     py::str s;
 };
 
+struct CustomData {
+    explicit CustomData(const std::string &a) : a(a) {}
+    std::string a;
+};
+
+struct MyException7 {
+    explicit MyException7(const CustomData &message) : message(message) {}
+    CustomData message;
+};
+
 TEST_SUBMODULE(exceptions, m) {
     m.def("throw_std_exception",
           []() { throw std::runtime_error("This exception was intentionally thrown."); });
@@ -385,4 +395,33 @@ TEST_SUBMODULE(exceptions, m) {
 
     // m.def("pass_exception_void", [](const py::exception<void>&) {}); // Does not compile.
     m.def("return_exception_void", []() { return py::exception<void>(); });
+
+    m.def("throws7", []() {
+        auto data = CustomData("abc");
+        throw MyException7(data);
+    });
+
+    py::class_<CustomData>(m, "CustomData", py::module_local())
+        .def(py::init<const std::string &>())
+        .def_readwrite("a", &CustomData::a);
+
+    PYBIND11_CONSTINIT static py::gil_safe_call_once_and_store<py::object>
+        PythonMyException7_storage;
+    PythonMyException7_storage.call_once_and_store_result([&]() {
+        auto mod = py::module_::import("custom_exceptions");
+        py::object obj = mod.attr("PythonMyException7");
+        return obj;
+    });
+
+    py::register_local_exception_translator([](std::exception_ptr p) {
+        try {
+            if (p) {
+                std::rethrow_exception(p);
+            }
+        } catch (const MyException7 &e) {
+            auto exc_type = PythonMyException7_storage.get_stored();
+            py::object exc_inst = exc_type(e.message);
+            PyErr_SetObject(PyExc_Exception, exc_inst.ptr());
+        }
+    });
 }
diff --git a/tests/test_exceptions.py b/tests/test_exceptions.py
index ba5063a74..a8fd105ea 100644
--- a/tests/test_exceptions.py
+++ b/tests/test_exceptions.py
@@ -3,6 +3,7 @@ from __future__ import annotations
 import sys
 
 import pytest
+from custom_exceptions import PythonMyException7
 
 import env
 import pybind11_cross_module_tests as cm
@@ -195,6 +196,10 @@ def test_custom(msg):
             raise RuntimeError("Exception error: caught child from parent") from err
     assert msg(excinfo.value) == "this is a helper-defined translated exception"
 
+    with pytest.raises(PythonMyException7) as excinfo:
+        m.throws7()
+    assert msg(excinfo.value) == "[PythonMyException7]: abc"
+
 
 def test_nested_throws(capture):
     """Tests nested (e.g. C++ -> Python -> C++) exception handling"""