diff --git a/docs/advanced/classes.rst b/docs/advanced/classes.rst
index 7bcd0385a..be4bc2e77 100644
--- a/docs/advanced/classes.rst
+++ b/docs/advanced/classes.rst
@@ -687,13 +687,15 @@ throwing a type error.
     complete example that demonstrates how to work with overloaded operators in
     more detail.
 
+.. _pickling:
+
 Pickling support
 ================
 
 Python's ``pickle`` module provides a powerful facility to serialize and
 de-serialize a Python object graph into a binary data stream. To pickle and
-unpickle C++ classes using pybind11, two additional functions must be provided.
-Suppose the class in question has the following signature:
+unpickle C++ classes using pybind11, a ``py::pickle()`` definition must be
+provided. Suppose the class in question has the following signature:
 
 .. code-block:: cpp
 
@@ -709,8 +711,9 @@ Suppose the class in question has the following signature:
         int m_extra = 0;
     };
 
-The binding code including the requisite ``__setstate__`` and ``__getstate__`` methods [#f3]_
-looks as follows:
+Pickling support in Python is enable by defining the ``__setstate__`` and
+``__getstate__`` methods [#f3]_. For pybind11 classes, use ``py::pickle()``
+to bind these two functions:
 
 .. code-block:: cpp
 
@@ -719,21 +722,28 @@ looks as follows:
         .def("value", &Pickleable::value)
         .def("extra", &Pickleable::extra)
         .def("setExtra", &Pickleable::setExtra)
-        .def("__getstate__", [](const Pickleable &p) {
-            /* Return a tuple that fully encodes the state of the object */
-            return py::make_tuple(p.value(), p.extra());
-        })
-        .def("__setstate__", [](Pickleable &p, py::tuple t) {
-            if (t.size() != 2)
-                throw std::runtime_error("Invalid state!");
+        .def(py::pickle(
+            [](const Pickleable &p) { // __getstate__
+                /* Return a tuple that fully encodes the state of the object */
+                return py::make_tuple(p.value(), p.extra());
+            },
+            [](py::tuple t) { // __setstate__
+                if (t.size() != 2)
+                    throw std::runtime_error("Invalid state!");
 
-            /* Invoke the in-place constructor. Note that this is needed even
-               when the object just has a trivial default constructor */
-            new (&p) Pickleable(t[0].cast<std::string>());
+                /* Create a new C++ instance */
+                Pickleable p(t[0].cast<std::string>());
 
-            /* Assign any additional state */
-            p.setExtra(t[1].cast<int>());
-        });
+                /* Assign any additional state */
+                p.setExtra(t[1].cast<int>());
+
+                return p;
+            }
+        ));
+
+The ``__setstate__`` part of the ``py::picke()`` definition follows the same
+rules as the single-argument version of ``py::init()``. The return type can be
+a value, pointer or holder type. See :ref:`custom_constructors` for details.
 
 An instance can now be pickled as follows:
 
diff --git a/docs/changelog.rst b/docs/changelog.rst
index 23d556370..478b7d7ab 100644
--- a/docs/changelog.rst
+++ b/docs/changelog.rst
@@ -91,6 +91,11 @@ v2.2.0 (Not yet released)
               return std::make_unique<Example>(std::to_string(n));
           }));
 
+* Similarly to custom constructors, pickling support functions are now bound
+  using the ``py::pickle()`` adaptor which improves type safety. See the
+  :doc:`upgrade` and :ref:`pickling` for details.
+  `#1038 <https://github.com/pybind/pybind11/pull/1038>`_.
+
 * Builtin support for converting C++17 standard library types and general
   conversion improvements:
 
diff --git a/docs/upgrade.rst b/docs/upgrade.rst
index 2fe8470b7..bcbc6b135 100644
--- a/docs/upgrade.rst
+++ b/docs/upgrade.rst
@@ -162,6 +162,39 @@ See :ref:`custom_constructors` for details.
         }));
 
 
+New syntax for pickling support
+-------------------------------
+
+Mirroring the custom constructor changes, ``py::pickle()`` is now the preferred
+way to get and set object state. See :ref:`pickling` for details.
+
+.. code-block:: cpp
+
+    // old -- deprecated
+    py::class<Foo>(m, "Foo")
+        ...
+        .def("__getstate__", [](const Foo &self) {
+            return py::make_tuple(self.value1(), self.value2(), ...);
+        })
+        .def("__setstate__", [](Foo &self, py::tuple t) {
+            new (&self) Foo(t[0].cast<std::string>(), ...);
+        });
+
+    // new
+    py::class<Foo>(m, "Foo")
+        ...
+        .def(py::pickle(
+            [](const Foo &self) { // __getstate__
+                return py::make_tuple(f.value1(), f.value2(), ...); // unchanged
+            },
+            [](py::tuple t) { // __setstate__, note: no `self` argument
+                return new Foo(t[0].cast<std::string>(), ...);
+                // or: return std::make_unique<Foo>(...); // return by holder
+                // or: return Foo(...); // return by value (move constructor)
+            }
+        ));
+
+
 Deprecation of some ``py::object`` APIs
 ---------------------------------------
 
diff --git a/include/pybind11/detail/init.h b/include/pybind11/detail/init.h
index ee2de8c2a..deace19c0 100644
--- a/include/pybind11/detail/init.h
+++ b/include/pybind11/detail/init.h
@@ -271,6 +271,55 @@ struct factory<CFunc, AFunc, CReturn(CArgs...), AReturn(AArgs...)> {
     }
 };
 
+/// Set just the C++ state. Same as `__init__`.
+template <typename Class, typename T>
+void setstate(value_and_holder &v_h, T &&result, bool need_alias) {
+    construct<Class>(v_h, std::forward<T>(result), need_alias);
+}
+
+/// Set both the C++ and Python states
+template <typename Class, typename T, typename O,
+          enable_if_t<std::is_convertible<O, handle>::value, int> = 0>
+void setstate(value_and_holder &v_h, std::pair<T, O> &&result, bool need_alias) {
+    construct<Class>(v_h, std::move(result.first), need_alias);
+    setattr((PyObject *) v_h.inst, "__dict__", result.second);
+}
+
+/// Implementation for py::pickle(GetState, SetState)
+template <typename Get, typename Set,
+          typename = function_signature_t<Get>, typename = function_signature_t<Set>>
+struct pickle_factory;
+
+template <typename Get, typename Set,
+          typename RetState, typename Self, typename NewInstance, typename ArgState>
+struct pickle_factory<Get, Set, RetState(Self), NewInstance(ArgState)> {
+    static_assert(std::is_same<RetState, ArgState>::value,
+                  "The type returned by `__getstate__` must be the same "
+                  "as the argument accepted by `__setstate__`");
+
+    remove_reference_t<Get> get;
+    remove_reference_t<Set> set;
+
+    pickle_factory(Get get, Set set)
+        : get(std::forward<Get>(get)), set(std::forward<Set>(set)) { }
+
+    template <typename Class, typename... Extra>
+    void execute(Class &cl, const Extra &...extra) && {
+        cl.def("__getstate__", std::move(get));
+
+#if defined(PYBIND11_CPP14)
+        cl.def("__setstate__", [func = std::move(set)]
+#else
+        auto &func = set;
+        cl.def("__setstate__", [func]
+#endif
+        (value_and_holder &v_h, ArgState state) {
+            setstate<Class>(v_h, func(std::forward<ArgState>(state)),
+                            Py_TYPE(v_h.inst) != v_h.type->type);
+        }, is_new_style_constructor(), extra...);
+    }
+};
+
 NAMESPACE_END(initimpl)
 NAMESPACE_END(detail)
 NAMESPACE_END(pybind11)
diff --git a/include/pybind11/pybind11.h b/include/pybind11/pybind11.h
index 16e3fdc3e..0e67c4060 100644
--- a/include/pybind11/pybind11.h
+++ b/include/pybind11/pybind11.h
@@ -1095,6 +1095,12 @@ public:
         return *this;
     }
 
+    template <typename... Args, typename... Extra>
+    class_ &def(detail::initimpl::pickle_factory<Args...> &&pf, const Extra &...extra) {
+        std::move(pf).execute(*this, extra...);
+        return *this;
+    }
+
     template <typename Func> class_& def_buffer(Func &&func) {
         struct capture { Func func; };
         capture *ptr = new capture { std::forward<Func>(func) };
@@ -1399,6 +1405,13 @@ Ret init(CFunc &&c, AFunc &&a) {
     return {std::forward<CFunc>(c), std::forward<AFunc>(a)};
 }
 
+/// Binds pickling functions `__getstate__` and `__setstate__` and ensures that the type
+/// returned by `__getstate__` is the same as the argument accepted by `__setstate__`.
+template <typename GetState, typename SetState>
+detail::initimpl::pickle_factory<GetState, SetState> pickle(GetState &&g, SetState &&s) {
+    return {std::forward<GetState>(g), std::forward<SetState>(s)};
+};
+
 NAMESPACE_BEGIN(detail)
 
 
diff --git a/tests/test_pickling.cpp b/tests/test_pickling.cpp
index 1e5f4ce74..821462ac4 100644
--- a/tests/test_pickling.cpp
+++ b/tests/test_pickling.cpp
@@ -25,6 +25,12 @@ TEST_SUBMODULE(pickling, m) {
         int m_extra1 = 0;
         int m_extra2 = 0;
     };
+
+    class PickleableNew : public Pickleable {
+    public:
+        using Pickleable::Pickleable;
+    };
+
     py::class_<Pickleable>(m, "Pickleable")
         .def(py::init<std::string>())
         .def("value", &Pickleable::value)
@@ -49,6 +55,23 @@ TEST_SUBMODULE(pickling, m) {
             p.setExtra2(t[2].cast<int>());
         });
 
+    py::class_<PickleableNew, Pickleable>(m, "PickleableNew")
+        .def(py::init<std::string>())
+        .def(py::pickle(
+            [](const PickleableNew &p) {
+                return py::make_tuple(p.value(), p.extra1(), p.extra2());
+            },
+            [](py::tuple t) {
+                if (t.size() != 3)
+                    throw std::runtime_error("Invalid state!");
+                auto p = PickleableNew(t[0].cast<std::string>());
+
+                p.setExtra1(t[1].cast<int>());
+                p.setExtra2(t[2].cast<int>());
+                return p;
+            }
+        ));
+
 #if !defined(PYPY_VERSION)
     // test_roundtrip_with_dict
     class PickleableWithDict {
@@ -58,6 +81,12 @@ TEST_SUBMODULE(pickling, m) {
         std::string value;
         int extra;
     };
+
+    class PickleableWithDictNew : public PickleableWithDict {
+    public:
+        using PickleableWithDict::PickleableWithDict;
+    };
+
     py::class_<PickleableWithDict>(m, "PickleableWithDict", py::dynamic_attr())
         .def(py::init<std::string>())
         .def_readwrite("value", &PickleableWithDict::value)
@@ -79,5 +108,23 @@ TEST_SUBMODULE(pickling, m) {
             /* Assign Python state */
             self.attr("__dict__") = t[2];
         });
+
+    py::class_<PickleableWithDictNew, PickleableWithDict>(m, "PickleableWithDictNew")
+        .def(py::init<std::string>())
+        .def(py::pickle(
+            [](py::object self) {
+                return py::make_tuple(self.attr("value"), self.attr("extra"), self.attr("__dict__"));
+            },
+            [](py::tuple t) {
+                if (t.size() != 3)
+                    throw std::runtime_error("Invalid state!");
+
+                auto cpp_state = PickleableWithDictNew(t[0].cast<std::string>());
+                cpp_state.extra = t[1].cast<int>();
+
+                auto py_state = t[2].cast<py::dict>();
+                return std::make_pair(cpp_state, py_state);
+            }
+        ));
 #endif
 }
diff --git a/tests/test_pickling.py b/tests/test_pickling.py
index 6cbcdf516..707d34786 100644
--- a/tests/test_pickling.py
+++ b/tests/test_pickling.py
@@ -7,8 +7,10 @@ except ImportError:
     import pickle
 
 
-def test_roundtrip():
-    p = m.Pickleable("test_value")
+@pytest.mark.parametrize("cls_name", ["Pickleable", "PickleableNew"])
+def test_roundtrip(cls_name):
+    cls = getattr(m, cls_name)
+    p = cls("test_value")
     p.setExtra1(15)
     p.setExtra2(48)
 
@@ -20,8 +22,10 @@ def test_roundtrip():
 
 
 @pytest.unsupported_on_pypy
-def test_roundtrip_with_dict():
-    p = m.PickleableWithDict("test_value")
+@pytest.mark.parametrize("cls_name", ["PickleableWithDict", "PickleableWithDictNew"])
+def test_roundtrip_with_dict(cls_name):
+    cls = getattr(m, cls_name)
+    p = cls("test_value")
     p.extra = 15
     p.dynamic = "Attribute"