diff --git a/tools/setup_main.py.in b/tools/setup_main.py.in
index bcd4ef4ae..533a75ae7 100644
--- a/tools/setup_main.py.in
+++ b/tools/setup_main.py.in
@@ -32,6 +32,9 @@ setup(
     entry_points={
         "console_scripts": [
              "pybind11-config = pybind11.__main__:main",
+        ],
+        "pipx.run": [
+             "pybind11 = pybind11.__main__:main",
         ]
     },
     cmdclass=cmdclass