diff --git a/docs/advanced/classes.rst b/docs/advanced/classes.rst
index 01a490b72..abde2c64f 100644
--- a/docs/advanced/classes.rst
+++ b/docs/advanced/classes.rst
@@ -903,6 +903,64 @@ are listed.
 
 .. _module_local:
 
+For more complex multiple-inheritance class architectures with virtual methods, it might be necessary to combine
+two different Trampoline class hierarchies. A templating trick can be used in this case to interleaf another
+trampoline class (-hierarchy):
+
+.. code-block:: cpp
+
+    class Animal {
+    public:
+        virtual ~Animal() { }
+        virtual std::string go(int n_times) = 0;
+    };
+    template <class AnimalBase = Animal>
+    class PyAnimal : public AnimalBase {
+    public:
+        using AnimalBase::AnimalBase; // Inherit constructors
+        std::string go(int n_times) override { PYBIND11_OVERRIDE_PURE(std::string, AnimalBase, go, n_times); }
+    };
+
+    class Dog : public Animal {
+    public:
+        std::string go(int n_times) override;
+    };
+    template <class DogBase = Dog>
+    class PyDog : public PyAnimal<DogBase> {
+    public:
+        using PyAnimal<DogBase>::PyAnimal; // Inherit constructors
+        std::string go(int n_times) override { PYBIND11_OVERRIDE(std::string, DogBase, go, n_times); }
+    };
+
+    class Mutant {
+    public:
+        virtual ~Mutant() { }
+        virtual void transform();
+    };
+    template <class MutantBase = Mutant, class PyMutantBase = MutantBase>
+    class PyMutant : public PyMutantBase {
+    public:
+        using PyMutantBase::PyMutantBase; // Inherit constructors
+        void transform() override { PYBIND11_OVERRIDE_PURE(void, MutantBase, transform, ); }
+    };
+
+    class Chimera : public Dog, public Mutant {
+    public:
+        virtual ~Chimera() { }
+    };
+    template <class ChimeraBase = Chimera>
+    class PyChimera : public PyMutant<ChimeraBase, PyDog<ChimeraBase>> {
+    public:
+        using PyMutant<ChimeraBase, PyDog<ChimeraBase>>::PyMutant; // Inherit constructors
+    };
+
+The class ``Chimera`` inherits from both ``Dog`` and ``Mutant`` both of which feature virtual methods and
+trampoline classes for binding. However, the ``Mutant`` trampoline class uses a second template parameter
+``PyMutantBase`` so it can be injected into the single inheritance structure required by a trampoline class.
+In effect, this mechanism enforces that the actual class the trampolines are using is only inherited from once.
+Since the trampolines only need to add their respective trampoline function registrations, the order of the
+inheritance of the various trampoline classes does not matter.
+
 Module-local class bindings
 ===========================
 
diff --git a/tests/test_multiple_inheritance.cpp b/tests/test_multiple_inheritance.cpp
index 5916ae901..c70bb529e 100644
--- a/tests/test_multiple_inheritance.cpp
+++ b/tests/test_multiple_inheritance.cpp
@@ -80,6 +80,59 @@ struct I801D : I801C {}; // Indirect MI
 
 } // namespace
 
+namespace TrampolineNesting {
+class ChainBaseA {
+public:
+    ChainBaseA() = default;
+    ChainBaseA(const ChainBaseA &) = default;
+    ChainBaseA(ChainBaseA &&) = default;
+    virtual ~ChainBaseA() = default;
+    virtual int resultA() { return 1; }
+};
+class ChainChildA : public ChainBaseA {
+public:
+    using ChainBaseA::ChainBaseA;
+    int resultA() override { return 2; }
+};
+class ChainBaseB {
+public:
+    ChainBaseB() = default;
+    ChainBaseB(const ChainBaseB &) = default;
+    ChainBaseB(ChainBaseB &&) = default;
+    virtual ~ChainBaseB() = default;
+    virtual std::string resultB() { return "A"; }
+};
+class ChainChildB : public ChainBaseB {
+public:
+    using ChainBaseB::ChainBaseB;
+    std::string resultB() override { return "B"; }
+};
+class Joined : public ChainChildA, public ChainChildB {
+public:
+    Joined() = default;
+    Joined(const Joined &) = default;
+    Joined(Joined &&) = default;
+};
+
+template <class Base = ChainBaseA>
+class TrampolineA : public Base {
+public:
+    using Base::Base;
+    int resultA() override { PYBIND11_OVERLOAD(int, Base, resultA, ); }
+};
+template <class Base = ChainBaseB, class PyBase = Base>
+class TrampolineB : public PyBase {
+public:
+    using PyBase::PyBase;
+    std::string resultB() override { PYBIND11_OVERLOAD(std::string, Base, resultB, ); }
+};
+template <class Base = Joined>
+class TrampolineJoined : public TrampolineB<Base, TrampolineA<Base>> {
+public:
+    using TrampolineB<Base, TrampolineA<Base>>::TrampolineB;
+};
+} // namespace TrampolineNesting
+
 TEST_SUBMODULE(multiple_inheritance, m) {
     // Please do not interleave `struct` and `class` definitions with bindings code,
     // but implement `struct`s and `class`es in the anonymous namespace above.
@@ -338,4 +391,19 @@ TEST_SUBMODULE(multiple_inheritance, m) {
         .def("get_f_e", &MVF::get_f_e)
         .def("get_f_f", &MVF::get_f_f)
         .def_readwrite("f", &MVF::f);
+
+    namespace TN = TrampolineNesting;
+
+    py::class_<TN::ChainBaseA, TN::TrampolineA<>>(m, "ChainBaseA")
+        .def(py::init<>())
+        .def("resultA", &TN::ChainBaseA::resultA);
+    py::class_<TN::ChainChildA, TN::ChainBaseA, TN::TrampolineA<TN::ChainChildA>>(m, "ChainChildA")
+        .def(py::init<>());
+    py::class_<TN::ChainBaseB, TN::TrampolineB<>>(m, "ChainBaseB")
+        .def(py::init<>())
+        .def("resultB", &TN::ChainBaseB::resultB);
+    py::class_<TN::ChainChildB, TN::ChainBaseB, TN::TrampolineB<TN::ChainChildB>>(m, "ChainChildB")
+        .def(py::init<>());
+    py::class_<TN::Joined, TN::ChainBaseA, TN::ChainBaseB, TN::TrampolineJoined<>>(m, "Joined")
+        .def(py::init<>());
 }
diff --git a/tests/test_multiple_inheritance.py b/tests/test_multiple_inheritance.py
index 3a1d88d71..e6acc2939 100644
--- a/tests/test_multiple_inheritance.py
+++ b/tests/test_multiple_inheritance.py
@@ -491,3 +491,12 @@ def test_python_inherit_from_mi():
     assert o.g == 7
 
     assert o.get_g_g() == 7
+
+
+def test_trampoline_nesting():
+    assert m.ChainBaseA().resultA() == 1
+    assert m.ChainChildA().resultA() == 2
+    assert m.ChainBaseB().resultB() == "A"
+    assert m.ChainChildB().resultB() == "B"
+    assert m.Joined().resultA() == 2
+    assert m.Joined().resultB() == "B"